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SCIENTIFIC SCORE
Possibly Effective
Based on 32 Researches
7.7
USERS' SCORE
Good
Based on 13 Reviews
8.7
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Calories
10
Total Fat
1 g
1%*
Polyunsaturated Fat
1 g
†
Fish Oil Concentrate
1 g (1,000 mg)
†
Docosahexaenoic Acid (DHA)
500 mg
†
Eicosapentaenoic Acid (EPA)
250 mg
†
Top Medical Research Studies
9
DHA aids post-heart attack recovery
The polyunsaturated fatty acids, EPA and DHA, ameliorate myocardial infarction-induced heart failure by inhibiting p300-HAT activity in rats.
Relevant to myocardial infarction treatments
We explored the effects of docosahexaenoic acid (DHA) on heart attack recovery in rats. The study aimed to understand how DHA, alongside eicosapentaenoic acid (EPA), can influence heart failure following myocardial infarction (MI).
Using several groups of rats experiencing moderate heart issues, we evaluated how these omega-3 fatty acids impacted heart function. We found that both DHA and EPA effectively curtailed the hypertrophic response in heart cells. This response is a significant factor in heart failure, where heart tissue thickens and hardens.
Notably, both DHA and EPA inhibited the activity of a histone acetyltransferase called p300. This activity is linked to molecular changes that promote heart cell enlargement and fibrosis. In our analysis, we observed that these fatty acids not only preserved cardiac function but also prevented structural changes common after a heart attack.
Overall, we noted that DHA had a comparable protective effect to EPA, significantly improving heart health and reducing fibrosis in the heart tissue. As such, the findings suggest that incorporating DHA could be a heart-friendly choice post-heart attack.
Using several groups of rats experiencing moderate heart issues, we evaluated how these omega-3 fatty acids impacted heart function. We found that both DHA and EPA effectively curtailed the hypertrophic response in heart cells. This response is a significant factor in heart failure, where heart tissue thickens and hardens.
Notably, both DHA and EPA inhibited the activity of a histone acetyltransferase called p300. This activity is linked to molecular changes that promote heart cell enlargement and fibrosis. In our analysis, we observed that these fatty acids not only preserved cardiac function but also prevented structural changes common after a heart attack.
Overall, we noted that DHA had a comparable protective effect to EPA, significantly improving heart health and reducing fibrosis in the heart tissue. As such, the findings suggest that incorporating DHA could be a heart-friendly choice post-heart attack.
Read More
9
Eicosapentaenoic acid aids heart recovery
Eicosapentaenoic Acid Preserves Mitochondrial Quality and Attenuates Cardiac Remodeling After Myocardial Infarction in Rats.
Significant effects on cardiac remodeling
We investigated how eicosapentaenoic acid (EPA) may help improve heart health after a heart attack. In our study, we induced myocardial infarction (MI) in male rats by ligating their coronary artery. Some of these rats received daily treatment with EPA, while others did not, allowing us to compare the effects.
Over 12 weeks, we observed that the rats treated with EPA showed better left ventricular function—essentially, their hearts were working more efficiently. Moreover, these rats had higher levels of EPA in their mitochondria, which are the energy factories of cells. Despite the damage caused by the heart attack, the EPA treatment helped maintain crucial energy levels and kept the mitochondrial function from declining, preserving a specific protein linked to cellular health.
Our findings suggest that including EPA in the diet can bolster mitochondrial quality and support heart function after an MI. This could mean that EPA may serve as an important dietary addition for promoting heart health following heart events.
Over 12 weeks, we observed that the rats treated with EPA showed better left ventricular function—essentially, their hearts were working more efficiently. Moreover, these rats had higher levels of EPA in their mitochondria, which are the energy factories of cells. Despite the damage caused by the heart attack, the EPA treatment helped maintain crucial energy levels and kept the mitochondrial function from declining, preserving a specific protein linked to cellular health.
Our findings suggest that including EPA in the diet can bolster mitochondrial quality and support heart function after an MI. This could mean that EPA may serve as an important dietary addition for promoting heart health following heart events.
Read More
9
DHA supports heart recovery post-MI
Metabolic transformation of fat in obesity determines the inflammation resolving capacity of splenocardiac and cardiorenal networks in heart failure.
Study shows DHA's positive role
We investigated how docosahexaenoic acid (DHA), a type of omega-3 fatty acid, influences recovery following a heart attack (MI) in the context of dietary fat intake. The study began by feeding mice with safflower oil (rich in omega-6 fatty acids) for 12 weeks, followed by DHA supplementation for another 8 weeks before inducing a heart attack.
Through this process, we observed that the early intake of safflower oil led to heightened inflammation, delaying the body’s ability to heal. However, when we supplemented with DHA, we noted a favorable shift. DHA increased the levels of specialized proresolving mediators (SPMs) that help the body resolve inflammation. These mediators seemed to counteract the negative effects of safflower oil by enhancing mechanisms in both the heart and kidneys critical for recovery post-MI.
Additionally, DHA contributed to an increase in resolving macrophages, which play a vital role in repairing the heart, and it also elevated T regulatory cells in the heart tissue during chronic heart failure. This might suggest that transitioning from a diet high in omega-6 fatty acids to one rich in omega-3s like DHA could improve outcomes after heart attacks.
Overall, while excessive safflower oil intake worsens inflammation and affects heart recovery, DHA promotes a healthier resolving phase, supporting better heart and kidney function in the aftermath of a heart attack.
Through this process, we observed that the early intake of safflower oil led to heightened inflammation, delaying the body’s ability to heal. However, when we supplemented with DHA, we noted a favorable shift. DHA increased the levels of specialized proresolving mediators (SPMs) that help the body resolve inflammation. These mediators seemed to counteract the negative effects of safflower oil by enhancing mechanisms in both the heart and kidneys critical for recovery post-MI.
Additionally, DHA contributed to an increase in resolving macrophages, which play a vital role in repairing the heart, and it also elevated T regulatory cells in the heart tissue during chronic heart failure. This might suggest that transitioning from a diet high in omega-6 fatty acids to one rich in omega-3s like DHA could improve outcomes after heart attacks.
Overall, while excessive safflower oil intake worsens inflammation and affects heart recovery, DHA promotes a healthier resolving phase, supporting better heart and kidney function in the aftermath of a heart attack.
Read More
Most Useful Reviews
9.5
Supports heart health
I started using this supplement for my heart and vascular system. At 27, I experienced heart tingling which was concerning. Despite taking various vitamins and coenzyme q10, I found my omega-3 levels were low. After starting omega-3, my heart issues resolved. I hope this helps others too!
Read More
9.5
Reduced cholesterol levels
This product has been outstanding for heart health. After following Dr Oz's advice, my husband and I saw our CRP levels drop significantly after eight months. No adverse effects either. Wishing everyone good health!
Read More
9.5
Supports male fertility
DHA is essential for health. I advised a friend to take DHA-500 for better heart and men's health, and it helped him conceive within a month. It is crucial for sperm motility and overall vitality.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 32 Researches
7.7
9
DHA aids post-heart attack recovery
The polyunsaturated fatty acids, EPA and DHA, ameliorate myocardial infarction-induced heart failure by inhibiting p300-HAT activity in rats.
Relevant to myocardial infarction treatments
We explored the effects of docosahexaenoic acid (DHA) on heart attack recovery in rats. The study aimed to understand how DHA, alongside eicosapentaenoic acid (EPA), can influence heart failure following myocardial infarction (MI).
Using several groups of rats experiencing moderate heart issues, we evaluated how these omega-3 fatty acids impacted heart function. We found that both DHA and EPA effectively curtailed the hypertrophic response in heart cells. This response is a significant factor in heart failure, where heart tissue thickens and hardens.
Notably, both DHA and EPA inhibited the activity of a histone acetyltransferase called p300. This activity is linked to molecular changes that promote heart cell enlargement and fibrosis. In our analysis, we observed that these fatty acids not only preserved cardiac function but also prevented structural changes common after a heart attack.
Overall, we noted that DHA had a comparable protective effect to EPA, significantly improving heart health and reducing fibrosis in the heart tissue. As such, the findings suggest that incorporating DHA could be a heart-friendly choice post-heart attack.
Using several groups of rats experiencing moderate heart issues, we evaluated how these omega-3 fatty acids impacted heart function. We found that both DHA and EPA effectively curtailed the hypertrophic response in heart cells. This response is a significant factor in heart failure, where heart tissue thickens and hardens.
Notably, both DHA and EPA inhibited the activity of a histone acetyltransferase called p300. This activity is linked to molecular changes that promote heart cell enlargement and fibrosis. In our analysis, we observed that these fatty acids not only preserved cardiac function but also prevented structural changes common after a heart attack.
Overall, we noted that DHA had a comparable protective effect to EPA, significantly improving heart health and reducing fibrosis in the heart tissue. As such, the findings suggest that incorporating DHA could be a heart-friendly choice post-heart attack.
Read More
9
DHA supports heart recovery post-MI
Metabolic transformation of fat in obesity determines the inflammation resolving capacity of splenocardiac and cardiorenal networks in heart failure.
Study shows DHA's positive role
We investigated how docosahexaenoic acid (DHA), a type of omega-3 fatty acid, influences recovery following a heart attack (MI) in the context of dietary fat intake. The study began by feeding mice with safflower oil (rich in omega-6 fatty acids) for 12 weeks, followed by DHA supplementation for another 8 weeks before inducing a heart attack.
Through this process, we observed that the early intake of safflower oil led to heightened inflammation, delaying the body’s ability to heal. However, when we supplemented with DHA, we noted a favorable shift. DHA increased the levels of specialized proresolving mediators (SPMs) that help the body resolve inflammation. These mediators seemed to counteract the negative effects of safflower oil by enhancing mechanisms in both the heart and kidneys critical for recovery post-MI.
Additionally, DHA contributed to an increase in resolving macrophages, which play a vital role in repairing the heart, and it also elevated T regulatory cells in the heart tissue during chronic heart failure. This might suggest that transitioning from a diet high in omega-6 fatty acids to one rich in omega-3s like DHA could improve outcomes after heart attacks.
Overall, while excessive safflower oil intake worsens inflammation and affects heart recovery, DHA promotes a healthier resolving phase, supporting better heart and kidney function in the aftermath of a heart attack.
Through this process, we observed that the early intake of safflower oil led to heightened inflammation, delaying the body’s ability to heal. However, when we supplemented with DHA, we noted a favorable shift. DHA increased the levels of specialized proresolving mediators (SPMs) that help the body resolve inflammation. These mediators seemed to counteract the negative effects of safflower oil by enhancing mechanisms in both the heart and kidneys critical for recovery post-MI.
Additionally, DHA contributed to an increase in resolving macrophages, which play a vital role in repairing the heart, and it also elevated T regulatory cells in the heart tissue during chronic heart failure. This might suggest that transitioning from a diet high in omega-6 fatty acids to one rich in omega-3s like DHA could improve outcomes after heart attacks.
Overall, while excessive safflower oil intake worsens inflammation and affects heart recovery, DHA promotes a healthier resolving phase, supporting better heart and kidney function in the aftermath of a heart attack.
Read More
9
DHA supports heart recovery
Docosahexaenoic Acid-Enhanced Autophagic Flux Improves Cardiac Dysfunction after Myocardial Infarction by Targeting the AMPK/mTOR Signaling Pathway.
Strong focus on DHA effects
We set out to explore how docosahexaenoic acid (DHA), a beneficial omega-3 fatty acid found in fish oil and seaweed, might play a role in heart health, particularly after a heart attack. Our findings stemmed from experiments on both isolated heart cells under low oxygen conditions and live mice experiencing myocardial infarction (MI), which is the medical term for a heart attack.
The results were promising. We observed that DHA not only improved cell survival in stressed heart cells but also minimized damage in mice following a heart attack. Specifically, we noted a reduction in heart injury and a boost in heart function, highlighting DHA's potential as a protective agent.
Importantly, we found that DHA enhances autophagy—a natural process that cleans out damaged cells—by activating specific signaling pathways in the body. We established that in both our test models, the presence of DHA led to less cell death and richer heart function recovery. However, when we inhibited the autophagy process in experiments, the protective advantages of DHA were lost, underscoring its reliance on this cell-cleaning mechanism.
Our study indicates that DHA may serve as a valuable aid in healing the heart after a heart attack by promoting processes that protect against cell damage. Balancing scientific insight with real-world implications offers a promising avenue for heart health strategies, especially for those recovering from myocardial infarction.
The results were promising. We observed that DHA not only improved cell survival in stressed heart cells but also minimized damage in mice following a heart attack. Specifically, we noted a reduction in heart injury and a boost in heart function, highlighting DHA's potential as a protective agent.
Importantly, we found that DHA enhances autophagy—a natural process that cleans out damaged cells—by activating specific signaling pathways in the body. We established that in both our test models, the presence of DHA led to less cell death and richer heart function recovery. However, when we inhibited the autophagy process in experiments, the protective advantages of DHA were lost, underscoring its reliance on this cell-cleaning mechanism.
Our study indicates that DHA may serve as a valuable aid in healing the heart after a heart attack by promoting processes that protect against cell damage. Balancing scientific insight with real-world implications offers a promising avenue for heart health strategies, especially for those recovering from myocardial infarction.
Read More
9
Omega-3s reduce heart attack risk
A Bayesian Analysis of the VITAL Trial: Effects of Omega-3 Fatty Acid Supplementation on Cardiovascular Events.
Clear links to heart attacks
We examined the effects of eicosapentaenoic acid (EPA), a type of omega-3 fatty acid, on the risk of heart attacks through a comprehensive analysis of the VITAL trial. This significant study included nearly 26,000 older adults in the U.S. who were monitored over an average of 5.3 years.
The original trial didn't find significant results for major cardiovascular events overall, but our Bayesian analysis suggested a different insight. By incorporating previous research and evidence, we discovered that daily supplementation with EPA appears to notably lower the risk of coronary heart disease events, particularly heart attacks.
However, the same beneficial effects did not extend to strokes or overall cardiovascular death, which means while we do see an encouraging trend for heart attacks, the evidence doesn't support a broad impact on other cardiovascular-related issues. Our findings help reinforce the value of omega-3 fatty acid supplementation as a preventive measure specifically for heart attacks.
The original trial didn't find significant results for major cardiovascular events overall, but our Bayesian analysis suggested a different insight. By incorporating previous research and evidence, we discovered that daily supplementation with EPA appears to notably lower the risk of coronary heart disease events, particularly heart attacks.
However, the same beneficial effects did not extend to strokes or overall cardiovascular death, which means while we do see an encouraging trend for heart attacks, the evidence doesn't support a broad impact on other cardiovascular-related issues. Our findings help reinforce the value of omega-3 fatty acid supplementation as a preventive measure specifically for heart attacks.
Read More
9
Eicosapentaenoic acid aids recovery
Elevated eicosapentaenoic acid to arachidonic acid ratio and rapid coronary blood flow restoration in ST-elevation myocardial infarction.
Relevant to heart attack recovery
We explored the role of eicosapentaenoic acid (EPA) in heart attack recovery, particularly its effect on restoring blood flow during ST-elevation myocardial infarction (STEMI). Our focus was on understanding whether higher levels of EPA relative to arachidonic acid could lead to faster recovery and better outcomes for patients experiencing this type of heart attack.
The study revealed that patients with elevated EPA levels indeed showed quicker restoration of coronary blood flow. This is promising, as efficient blood flow restoration is critical in minimizing heart damage during a heart attack. However, it’s essential to note that the effectiveness of EPA may vary based on other treatments the patients are receiving.
These findings suggest a positive link between EPA and heart attack recovery, but further investigation is necessary to determine the best approaches for integrating EPA into treatment protocols. Ultimately, while we observed encouraging results, the interplay between dietary interventions and other medical treatments warrants additional research.
The study revealed that patients with elevated EPA levels indeed showed quicker restoration of coronary blood flow. This is promising, as efficient blood flow restoration is critical in minimizing heart damage during a heart attack. However, it’s essential to note that the effectiveness of EPA may vary based on other treatments the patients are receiving.
These findings suggest a positive link between EPA and heart attack recovery, but further investigation is necessary to determine the best approaches for integrating EPA into treatment protocols. Ultimately, while we observed encouraging results, the interplay between dietary interventions and other medical treatments warrants additional research.
Read More
User Reviews
USERS' SCORE
Good
Based on 13 Reviews
8.7
9.5
Supports heart health
I started using this supplement for my heart and vascular system. At 27, I experienced heart tingling which was concerning. Despite taking various vitamins and coenzyme q10, I found my omega-3 levels were low. After starting omega-3, my heart issues resolved. I hope this helps others too!
Read More
9.5
Reduced cholesterol levels
This product has been outstanding for heart health. After following Dr Oz's advice, my husband and I saw our CRP levels drop significantly after eight months. No adverse effects either. Wishing everyone good health!
9.5
Supports cardiovascular health
The BEST MEGA-O! Since my Multiple Sclerosis diagnosis, this supplement has been lifesaving. Along with antioxidants, it has positively influenced my health, reducing inflammation and normalising cholesterol while improving heart health.
9.5
Promotes heart health
"Ultra Omega-3" by Now Foods enhances overall health. Its ingredients are beneficial for the cardiovascular system, helping with blood flow and reducing heart attack risks. I recommend taking one capsule daily.
9.5
Supports male fertility
DHA is essential for health. I advised a friend to take DHA-500 for better heart and men's health, and it helped him conceive within a month. It is crucial for sperm motility and overall vitality.
